NAD+ is a coenzyme found in every living cell — essential for energy metabolism, DNA repair, and cellular signaling. Levels decline with age. Restoring them is one of the most promising frontiers in longevity science.
NAD+ supplementation is one of the most actively researched interventions in aging science. Here's what the clinical evidence demonstrates.
NAD+ is essential for mitochondrial function and ATP synthesis — the energy currency of every cell. As NAD+ declines with age, so does your cellular energy capacity. Restoring NAD+ levels directly supports mitochondrial efficiency.
NAD+ is required by sirtuins and PARPs — the enzymes responsible for DNA repair, stress response, and metabolic regulation. Restoring NAD+ levels supports your cells' ability to repair damage and respond to oxidative stress, mechanisms central to healthy aging.
Clinical trials consistently show that NAD+ precursors safely and significantly elevate blood NAD+ levels — approximately 40% with standard dosing and up to 90% with higher doses, with effects sustained over weeks of supplementation.
NAD+ is a cofactor central to brain energy metabolism. Clinical studies show NAD+ precursors cross into the central nervous system and are being actively investigated for cognitive protection in aging and neurodegenerative conditions.
A pilot clinical trial found that nicotinamide riboside supplementation reduced oxidative stress, increased nitric oxide production, and improved mitochondrial efficiency in vascular endothelial cells — supporting cardiovascular function.
NAD+ is a required substrate for sirtuins — a family of proteins that regulate DNA repair, inflammation, and cellular stress responses. Declining NAD+ impairs sirtuin function; restoring it reactivates these critical longevity pathways.
Your ALYZE practitioner reviews your biomarkers, metabolic health, and goals to determine whether IV NAD+, oral precursors (NR or NMN), or a combined protocol is right for you.
For maximum impact, IV NAD+ delivers the coenzyme directly to your bloodstream. Sessions typically last 2–4 hours depending on dose (250–1000mg). The infusion rate is carefully controlled to minimize discomfort.
You may experience chest tightness, warmth, or mild nausea during the infusion — this is normal and subsides when the rate is adjusted. Your ALYZE team monitors you throughout and adjusts the drip speed as needed.
After your initial IV series, your practitioner may recommend daily oral NAD+ precursors (NR or NMN) to maintain elevated levels between IV sessions. Dosing is based on your response and lab values.
NAD+ levels are monitored through follow-up labs. Your protocol evolves — frequency of IV sessions, oral dosing, and complementary interventions are all adjusted based on biomarker response and clinical outcomes.
Important: IV NAD+ therapy should be administered by qualified medical professionals in a clinical setting. Inform your practitioner of all medications and health conditions — NAD+ may interact with certain chemotherapy agents and immunosuppressants. If you experience severe chest pressure, difficulty breathing, or persistent nausea during infusion, alert your practitioner immediately. Individuals with active cancer should consult their oncologist before NAD+ supplementation.
NAD+ science is advancing rapidly, with multiple human clinical trials now published. These are the landmark studies.
Recent peer-reviewed studies on NAD+ therapy and precursors, automatically sourced from PubMed.
NAD+ therapy is one piece of your personalized precision medicine plan — informed by your bloodwork, biomarkers, and health goals.
Bountiful, Utah · alyze.health
The information provided on this page is for general informational and educational purposes only and is not intended as medical advice. The research cited is from peer-reviewed journals and is presented for educational purposes. Individual results may vary. Always consult with a qualified healthcare provider before beginning any new wellness practice, including NAD+ therapy.
